Preparation, Evaluation and Comparison of Lipid Based Drug Delivery Systems of Tacrolimus

Objective: To prepare and evaluate lipid based drug delivery systems of Tacrolimus. Methods: Lipid based solid dispersion (SD) and self microemulsifying drug delivery systems (SMEDDS) of Tacrolimus are prepared and evaluated. Firstly, solid dispersions, liquid and solid self microemulsifying drug delivery systems of Tacrolimus were prepared. Prepared formulations were evaluated by dissolution test. The optimised formulation of Tacrolimus was subjected for invitro metabolism and intestinal permeation studies for comparison with marketed preparation (Pangraf 5 mg) and pure drug powder. Results: Among four different formulations, the liquid SMEDDS showed significantly higher dissolution rate. This optimised formulation also showed lower rate of drug metabolism and higher intestinal permeation rate compared to marketed preparation and pure drug powder. Conclusion: In this study, we have successfully prepared liquid SMEDDS which showed significantly higher dissolution rate, intestinal permeability and lower rate of drug metabolism.